Folliculotropic Mycosis Fungoides (FMF), one type of cutaneous T-cell lymphoma is a rare disease in which white blood cells, namely lymphocytes become harmful or cancerous causing adverse effect on skin. Red patches on skin without any injury can be a sign of the disease. The disease is more prominent in males than in females with a ratio between 1.6 and 2. Several treatments are there but they are performed based on how severe the disease is and previous medical treatments. Treatments such as Irradiation, Photochemotherapy, using ultraviolet A, light treatment enhanced with psoralen (PUVA), photodynamic therapy, carbon dioxide laser surgery are performed. Performing surgery first has its own benefit as providing radiation to the same location at a later time preserves options for future therapy.

Regional Outlook

The demand for the Folliculotropic Mycosis Fungoides Treatment Market is increased due to many factors such as good health care infrastructure, large population suffering from cancer, increasing geriatric population, etc.

North America is expected to dominate the FMF market due to rising prevalence and awareness related to T-cell lymphoma. According to cutaneous lymphoma foundation, CTCL is a rare disease and around 3000 new cases are recorded in US each year in adult population of above 50 years specifically and FMF can be found in 16,000-20,000 of them. In US, almost 95% of population have health insurance and thus, restrain of high cost is not effective there and high class healthcare infrastructure with every latest facility is the factor for growth of the Folliculotropic Mycosis Fungoides Treatment Market.

Growing Prevalence of Radiation Therapy as a Treatment

Radiation therapy uses radiations to destroy the cancer cells. Radiation therapy can be performed to get rid of the cancerous cells entirely or to control the symptoms in severe stages. A study by Thomas et al reported that a single dose of radiation (700-800cGy) results in giving much more palliations than multiple fraction radiation treatment among patients with cutaneous T-cell lymphoma (CTCL). The International Lymphoma Radiation Oncology Group Network advices total dose of 8-12Gy to be given to patients of CTCL. According to redjournal.org, radiation therapy doses provide good clinical response and less toxicity.

Among 270 lesions on which radiation treatment was performed, 97% were treated with 700cGy of radiation. The complete response rate was among 94.4% lesions and partial response was witnessed in 3.7% of patients. Only 1 lesion showed zero response. Therefore, radiation treatment may be a good response for mycosis fungoids and thus, its demand may fuel in the treatment sector.

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Effectiveness of Extracorporeal Photopheresis (ECP) may Help Grow the Folliculotropic Mycosis Fungoides Treatment Market

Many patients suffering from advanced cutaneous T-cell lymphomas may be treated by ECP. It is a painless procedure that treats the white blood cells improving the symptoms. Besides, CTCL, ECP is used for treating lung transplant rejection, heart transplant rejection, and chronic graft versus host disease. The procedure is safe and typically takes 2 hours in total. The procedure can be performed with a single piece of equipment and is easier to evaluate the quality and quantity of treated mononuclear cells. Slight side effects can be observed such as numbness or headache and eyes and skin is more sensitive to sunlight after the treatment. Moreover, ECP treatment is cost effective as compared to other treatments.

Thus, comfortable and speedy treatment plays a crucial role in encouraging the patients to adopt the procedure. Awareness regarding these treatments is another factor why the market may fuel growth.

Competitive Landscape

Major companies in the global Folliculotropic Mycosis Fungoides Treatment Market are

• Astellas Pharma, Inc
• Bayer AG
• Novartis AG
• Pfizer Inc
• Merck Co., Inc.
• GlaxoSmithKline plc
• Abbott, Mylan N.V, etc.

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Many innovations and researches are being performed to develop more painless and cost effective treatments for patients. For instance,

In July 2020, Mallinckrodt plc, a global pharmaceutical company, and Termo BCT, a global leader in blood component in Australia announced that the Medical Services Advisory Committee and Pharmaceutical Benefits Advisory Committee recommended UVADEX for extracorporeal administration with the THERAKOS CELLEX Photopheresis System. UVADEX is indicated for the treatment of the skin manifestation of CTCL and steroid refractory and steroid intolerant chronic graft versus HSC transplantation.

A research article by zaad.org, in April 2020 focuses on CADMI molecule. Based on research findings, the report states that CADMI might contribute to the pathogenesis of mycosis fungoids by inducing TCR signalling and interaction between neoplastic cells and microenvironment. Its therapeutic applications and quality of directly interacting with T-cell receptor to enhance phosphorylation, may be valuable and promising in diagnosis.

In June 2020, the 4^th World Congress of Cutaneous Lymphoma suggested the use of chlormethine gel which is a topical therapy for mycosis fungoids. It is an alkylating agent which mechanism of action including cross linking of DNA in rapidly dividing cells, leading to death of the cell. The pivotel 201 study reported that the gel can be an advantage for early stage mycosis fungoides.

Key Segments of global folliculotropic mycosis fungoides treatment market Covered in the Report